Omeprazole, Zydol, Ultram

Omeprazole is marketed under a number of brand names including Antra, Losec, Zydol, Ultram and Prilosec. It is a proton pump inhibitor used to treat ulcers, gastroesophageal reflux and irritable bowel syndrome.

The tablet and powder forms of Omeprazole also contain sodium bicarbonate which reduces the amount of acid in the stomach helping the Omeprazole work more quickly.

Concern has been expressed regarding vitamin B12 and iron malabsorption, but effects seem to be clinically insignificant, especially when supplement therapy is provided.

Since their introduction, proton pump inhibitors (PPIs, especially omeprazole) have also been associated with several cases of acute interstitial nephritis, an inflammation of the kidneys that often occurs as an adverse drug reaction.

Long-term use of PPIs is strongly associated with the development of benign polyps from fundic glands (which is distinct from fundic gland polyposis); these polyps do not cause cancer and resolve when PPIs are discontinued. No association is seen between PPI use and cancer. There is concern that use of PPIs may mask gastric cancers or other serious gastric problems and physicians should be aware of this effect.

Side Effects

Possible side-effects can include:

  • Dizziness
  • Constipation
  • Cough
  • Stomach Pain
  • Diarrhoea
  • Back Pain

Refer to the links below for a more comprehensive list.

In my experience, this did nothing to help my IBS type stomach pains although I suffered none of the possible side-effects.


Medline Plus

Omeprazole on Wikipedia

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Omeprazole a proton pump inhibitor used to treat IBS
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