Trimethoprim is a bacteriostatic antibiotic used mainly in the prevention and treatment of urinary tract infections.

It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Trimethoprim was formerly marketed by GlaxoSmithKline under trade names including Proloprim, Monotrim, and Triprim, but these trade names are now licensed to various generic pharmaceutical manufacturers.

Trimethoprim for Multiple Sclerosis

Strictly speaking, Trimethoprim is not for multiple sclerosis specifically, but it can be used to treat urinary tract infections or UTIs brought about by self-catheterization

If, as I do, you have a need to self-catheterise, it is likely that you will contract a bladder or urinary infection at some time. I have managed at least three over the past few years. Although it now appears that this may have been misleading.

Urine infection can lead to moderate discomfort, or, in my experience, quite severe pain. While bladder pain is not excruciating, any pain can be debilitating if it is persistent.

Trimethoprim is described as an antibacterial medicine which is prescribed to treat a bacterial infection of the urinary tract caused by organisms that are sensitive to Trimethoprim or as a preventative measure to avoid furture infections.

Drugs to avoid when taking Trimethoprim:

  • methotrexate
  • cyclophosphamide
  • Phenytoin
  • Digoxin
  • Rifampicin

I have used Trimethoprim only once, to my knowledge, and found it to be less than effective.

Possible Reactions

Trimethoprim can cause thrombocytopenia (low levels of platelets) by lowering folic acid levels; this may also cause megaloblastic anemia. Trimethoprim antagonises the epithelial sodium channel in the distal tubule, thus acting like amiloride. This can cause hyperkalemia. Trimethoprim also competes with creatinine for secretion into the renal tubule. This can cause an artefactual rise in the serum creatinine.


Trimethoprim in Wikipedia
Information specific to Trimethoprim – NHS Choices

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