Trimethoprim is a bacteriostatic antibiotic used mainly in the prevention and treatment of urinary tract infections.

It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Trimethoprim was formerly marketed by GlaxoSmithKline under trade names including Proloprim, Monotrim, and Triprim, but these trade names are now licensed to various generic pharmaceutical manufacturers.

Trimethoprim for Multiple Sclerosis

Trimethoprim combat bladder infectionStrictly speaking, Trimethoprim is not a drug targeted at or for multiple sclerosis specifically, but it can be used to treat urinary tract infections or UTIs brought about by self-catheterisation

If, as I do, you have a need to self-catheterise, it is likely that you will contract a bladder or urinary infection at some time. I have managed at least three over the past few years. Although it now appears that this may have been misleading.

Urine infection can lead to moderate discomfort, or, in my experience, quite severe pain. While bladder pain is not excruciating, any pain can be debilitating if it is persistent.

Trimethoprim is described as an antibacterial medicine which is prescribed to treat a bacterial infection of the urinary tract caused by organisms that are sensitive to Trimethoprim or as a preventative measure to avoid future infections.

Drugs to avoid when taking this medication:

  • methotrexate
  • cyclophosphamide
  • Phenytoin
  • Digoxin
  • Rifampicin

I have used this drug only once, to my knowledge, and found it to be less than effective.

Possible Reactions

Trimethoprim can cause thrombocytopenia (low levels of platelets) by lowering folic acid levels; this may also cause megaloblastic anemia. Trimethoprim antagonises the epithelial sodium channel in the distal tubule, thus acting like amiloride. This can cause hyperkalemia. This drug also competes with creatinine for secretion into the renal tubule. This can cause an artefactual rise in the serum creatinine.

I don’t know about you, but that list of possible reactions is a little bit scary. Coupled with the fact that this is a chemotherapeutic agent should make you think carefully before taking this medication.

As I often do, I will leave you with a link to my “Plethora Page” in case you should be interested:

A Plethora of Neurological Dysfunctions

This is not really a post I expect to attract much organic traffic. I created it more to keep a record of the different medications I have been prescribed over the years.

References

Trimethoprim in Wikipedia
Information specific to Trimethoprim – NHS Choices

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