Amitripyline for Multiple Sclerosis
Also: Elavil, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline
Amitriptyline Hydrochloride
Primarily an anti-depressant drug, Amitriptyline is marketed under a number of brand names including Elavil®, Tryptanol®, Endep®, Elatrol®, Tryptizol® and Trepiline®. It is a tricyclic antidepressant which inhibits serotonin and noradrenaline in the brain.
Approved Use
Amitriptyline is approved for the treatment of endogenous depression and involuntary melancholia.
Unapproved Use
Amitriptyline is also an effective pain-reliever and sleeping tablet and has many unapproved applications including:
- Insomnia
- Migraine
- Interstitial Cystitis
- Irritable Bowel Syndrome
- Paraesthesia in Multiple Sclerosis
Side Effects
It appears that Amitriptyline has an extensive list of possible side-effects which can include:
- Headaches
- Constipation
- Drowsiness
- Upset stomach
- Anxiety
- Hot Flushes
- Dry mouth
Refer to the links below for a more comprehensive list.
From my own experience, the drowsiness was the factor that precluded the long-term use of Amitriptyline. I was prescribed this drug for irritable bowel stomach pain which it did help with. However, the usual MS brain fog got so bad that I could not function. The fog was a zero-visibility low-cloud, I didn’t know what day it was and, had I tried, I probably couldn’t have tied my own shoelaces.
References
DISCLAIMER: The content of this site does not represent a qualified medical opinion. It is simply the information amassed by an MS patient while trying to understand this condition. You should seek the advice of your medical practitioner or neurologist before trying any treatment you may read about on this site. I am not a doctor, I am a patient.
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